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T2 and Cardiac Iron

T2* as a Measure of Cardiac Iron Burden

MRI has been investigated and shown to be a reliable tool for quantifying iron stores in cardiac tissue in addition to the liver and the anterior pituitary.1

Cardiac T2* as measured by MRI has been shown to be more reliable in determining iron loading in the heart when compared with liver iron concentrations and/or serum ferritin levels.2-4

Cardiac iron thresholds are indicated by T2* values3,5
  • <10 ms correlates with severe cardiac siderosis
  • 10-20 ms indicates mild-moderate cardiac iron toxicity
  • >20 ms is indicative of normal levels in the heart


EXJADE has been shown to reduce LIC and serum ferritin, and improve myocardial T2*.

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