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NTDT2

Starting EXJADE® treatment in NTDT patients with chronic iron overload

Measure iron overload with liver iron concentration (LIC)

LIC is the preferred method of iron overload determination and should be used wherever available. Caution should be taken during chelation therapy to minimize the risk of overchelation in all patients.

One course of treatment with EXJADE is recommended for patients with NTDT who achieve a satisfactory iron level.

Measure LIC or SF before initating therapy
NTDT Dosing and Administration Chart 1
EXJADE dosing for NTDT patients
NTDT Dosing and Administration Chart 2

SF, serum ferritin.
NTDT, non-transfusion-dependent thalassemia

Measure iron overload with liver iron concentration (LIC)

LIC is the preferred method of iron overload determination and should be used wherever available. Caution should be taken during chelation therapy to minimize the risk of overchelation in all patients.

One course of treatment with EXJADE is recommended for patients with NTDT who achieve a satisfactory iron level.

EXJADE dosing for NTDT patients
NTDT Dosing and Administration Chart 2

Pediatric NTDT patients

In patients 10 to 17 years of age, dosing should not exceed 10 mg/kg/day. LIC should be monitored every 3 months when SF is ≤800 μg/l in order to avoid overchelation.

Recommended monitoring during EXJADE treatment
NTDT Dosing and Administration Chart 3

Contraindications

EXJADE is contraindicated in:

  • patients with hypersensitivity to the active substance or the following excipients: lactose monohydrate; crospovidone type A; cellulose, microcrystalline; povidone; sodium lauryl sulfate; silica, colloidal anhydrous; magnesium stearate
  • combination with other iron chelator therapies as the safety of such combinations has not been established
  • patients with estimated creatinine clearance <60 ml/min

Warning

Data in children with NTDT are very limited. As a consequence, EXJADE therapy should be closely monitored to detect side effects and to follow iron burden in the pediatric population. In addition, before treating heavily iron-overloaded children with NTDT with EXJADE, the physician should be aware that the consequences of long-term exposure in such patients are currently not known.

EXJADE ADMINISTRATION

Help ensure your patients properly take their once-daily oral therapy

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