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Dosing and Administration for Myelodysplastic Syndromes

In transfusion-dependent, lower-risk MDS

EXJADE Offers Tailored Dosing to Meet Your Patients′ Needs

EXJADE® Starting and Escalation Dosages

Titrate and monitor to reach chelation goals

  • The recommended daily starting dose of EXJADE is 20 mg/kg body weight
  • Monitor serum ferritin monthly and assess trends with steady-state levels
  • Titrate EXJADE by steps of 5 mg/kg/day to 10 mg/kg/day every 3 to 6 months based on individual patient′s response and therapeutic goals (maintenance or reduction of iron)
  • EXJADE is approved in many countries at doses up to 40 mg/kg/day for patients not adequately controlled with doses of 30 mg/kg (eg, serum ferritin levels persistently above 2,500 μg/l and not showing a decreasing trend over time)
  • Doses above 40 mg/kg are not recommended because there is only limited experience with doses above this level
  • Dose reductions, in steps of 5 to 10 mg/kg, should be considered in patients whose serum ferritin levels have reached the target (usually between 500 and 1000 μg/L) in order to maintain serum ferritin levels within the target range
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LEARN MORE ABOUT EXJADE

Useful overview of relevant information for physicians new to EXJADE.

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CALCULATE MDS SEVERITY

Available for use online or as a downloadable version, the IPSS Calculator can help you determine the appropriate risk level of your MDS patients based on international consensus guidelines.

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