Home > Lower-risk Myelodysplastic Syndrome > Dosing & Administration
Dosing and Administration for Myelodysplastic Syndromes

In transfusion-dependent, lower-risk MDS

EXJADE Offers Tailored Dosing to Meet Your Patients′ Needs

EXJADE® Starting and Escalation Dosages

Titrate and monitor to reach chelation goals

  • The recommended daily starting dose of EXJADE is 20 mg/kg body weight
  • Monitor serum ferritin monthly and assess trends with steady-state levels
  • Titrate EXJADE by steps of 5 mg/kg/day to 10 mg/kg/day every 3 to 6 months based on individual patient′s response and therapeutic goals (maintenance or reduction of iron)
  • EXJADE is approved in many countries at doses up to 40 mg/kg/day for patients not adequately controlled with doses of 30 mg/kg (eg, serum ferritin levels persistently above 2,500 μg/l and not showing a decreasing trend over time)
  • Doses above 40 mg/kg are not recommended because there is only limited experience with doses above this level
  • Dose reductions, in steps of 5 to 10 mg/kg, should be considered in patients whose serum ferritin levels have reached the target (usually between 500 and 1000 μg/L) in order to maintain serum ferritin levels within the target range
Learn more about monitoring


Useful overview of relevant information for physicians new to EXJADE.

Learn more


Available for use online or as a downloadable version, the IPSS Calculator can help you determine the appropriate risk level of your MDS patients based on international consensus guidelines.

Learn more