The National Comprehensive Cancer Network (NCCN), an alliance of the world's leading cancer centers, recommends iron chelation therapy in its 2013 Practice Guidelines in Oncology. Specifically, chelation is recommended for low or intermediate-1 patients who2:
- Have received 20 transfusions
- Are expected to receive 20 transfusions
- Are expected to receive ongoing transfusions
- Have a serum ferritin level >2500 µg/L
The NCCN defines the goal of chelation therapy as decreasing ferritin levels to <1000 µg/L.